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Effect of hexachlorobenzene on enzymes of the steroid metabolism in rat liver

✍ Scribed by V. Graef; S. W. Golf; G. Goerz

Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
266 KB
Volume
43
Category
Article
ISSN
0340-5761

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✦ Synopsis

Adult female Wistar rats were fed with a diet containing 0.05% hexachlorobenzene. On the 60th day of this treatment the specific activities of NADPH: delta 4-3-oxosteroid-5 alpha-reductase and the 3-hydroxysteroid dehydrogenases in rat liver microsomes were diminished compared to control rats. The cytoplasmatic 5 beta-reduction was higher in HCB treated rats than in control rats. These alterations of the steroid metabolism lead to increased formation of 5 beta-H-steroids which are known to be inducers of the porphyrin biosynthesis.

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