## Abstract IFNβΞ± combined with ribavirin is used for the treatment of chronic hepatitis C. However, HCV has mechanisms to resist the antiviral actions of IFNβΞ±. In order to study the molecular mechanisms of this resistance, the effect of __HCV__ gene expression on IFNβinduced nuclear import of STA
Effect of hepatitis C virus core protein on interferon-induced antiviral genes expression and its mechanisms
β Scribed by Yan-zi Chang; Yan-chang Lei; Wen Wu; Shan-shan Chen; Han-ju Huang; Dong-liang Yang; Meng-ji Lu
- Book ID
- 107635937
- Publisher
- SP Wuhan Institute of Virology, CAS
- Year
- 2007
- Tongue
- English
- Weight
- 277 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1674-0769
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Interferons (IFNs) and the interferon-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We have reported previously that ISGs, including guanylate binding protein 1 (GBP-1), interferon alpha inducible protein (IFI)-6-16, and IFI-27, inhibit
We developed approaches using antisense RNA to inhibit hepatitis C virus (HCV) RNA translation and HCV core protein expression. An HCV genotype 1b cDNA comprising nt 1-1321 or a fusion construct consisting of HCV (nt 1-584) and luciferase cDNAs were inserted downstream of T7 and CMV promoter sequenc
## Abstract Response to ribavirin therapy (1,000β1,200 mg/day for 6 months) was evaluated in nine patients with chronic hepatitis C virus (HCV) infections who had previously failed to respond to a 6βmonth course of alphaβinterferon. All had chronic active hepatitis with elevated serum aminotransfer