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Effect of hematopoietic stem cell inhibitory factor on development of the immune response

โœ Scribed by D. R. Kaulen; T. A. Golovanova; O. Yu. Ignat'eva; E. B. Mysyakin

Publisher
Springer US
Year
1981
Tongue
English
Weight
246 KB
Volume
91
Category
Article
ISSN
0007-4888

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In vivo, stem cell factor (SCF) exists in both a bound and soluble isoform. It is believed that the bound form is more potent and fundamentally required for the maintenance of hematopoietic stem cells (HSCs). This theory is supported by the observation that steel-Dickie mice lacking the bound isofor