Effect of haemodialysis on the pharmacokinetics of cetirizine

✍ Scribed by W. M. Awni; J. Yeh; C. E. Halstenson; J. A. Opsahl; M. Chung; G. R. Matzke

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 316 KB
• Volume: 38
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00314806

✦ Synopsis

The pharmacokinetics of Cetirizine, a histamine H1-receptor antagonist, were investigated in five renal failure patients undergoing chronic haemodialysis therapy. The patients received one 10 mg cetirizine dihydrochloride capsule 3 h before haemodialysis. Concentrations of cetirizine in serum and dialysate were determined by HPLC. The maximum serum cetirizine concentration and the time to reach that maximum were 285 micrograms.l-1 and 2.0 h, respectively. The terminal disposition half-life of cetirizine in these patients was 19.3 h. The haemodialysis clearance of cetirizine was 14.0 ml. min-1. Although this is approximately 33% of the apparent total body clearance of cetirizine in subjects with normal renal function, the fraction of the dose removed by dialysis was only 9.4%. Thus, since haemodialysis does not produce a clinically significantly alteration in cetirizine elimination, no supplemental dose should be necessary after dialysis.