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Effect of H1-antihistamines on the oxidative burst of rat phagocytes

✍ Scribed by J. Kralova; M. Ciz; R. Nosal; K. Drabikova; A. Lojek

Publisher
SP Birkhäuser Verlag Basel
Year
2006
Tongue
English
Weight
53 KB
Volume
55
Category
Article
ISSN
1420-908X

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Structure-activity relationship studies were conducted to reduce CYP2D6-mediated metabolism in a series of indene H 1 -antihistamines. Reductions in pK a via incorporation of a b-fluoro substituent or a heteroaryl moiety were shown to reduce contributions to metabolism through this pathway. Several