## Abstract Tungstate treatment increases the phosphorylation of glycogen synthase kinaseโ3ฮฒ (GSK3ฮฒ) at serine 9, which triggers its inactivation both in cultured neural cells and in vivo. GSK3 phosphorylation is dependent on the activation of extracellular signalโregulated kinases 1/2 (ERK1/2) ind
โฆ LIBER โฆ
Effect of GSK-3 overactivation on neurofilament phosphorylation
โ Scribed by Chen Juan; Zhou Jie; Feng Youmei; Wang Janzhi
- Book ID
- 105624115
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- Chinese
- Weight
- 459 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0510-9752
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## Abstract The Ser493 residue in the Eโsegment of the rat neurofilament heavy chain (NFโH) is phosphorylated by glycogen synthase kinase 3ฮฒ (GSK3ฮฒ) in vitro and in spinal cord. We examined Ser493 phosphorylation by analyzing developmental changes and cellular distribution of phosphoโSer493 using p