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Effect of GM1 ganglioside on amnesia, convulsions and death caused by hypoxia in mice

✍ Scribed by Malcangio, M.; Pizzighelli, L.; Fantetti, L.; Ghelardini, C.; Giotti, A.; Malmberg-Aiello, P.; Bartolini, A.

Book ID: 123402749
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 70 KB
Volume: 22
Category: Article
ISSN: 1043-6618
DOI: 10.1016/S1043-6618(09)80320-4

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Adult male Fischer-344 rats were given bilateral injections of 2.5 micrograms colchicine or artificial cerebrospinal fluid into caudal and rostral sites of the dentate gyrus of the hippocampus. One group of rats received 21 consecutive daily injections of 20 mg/kg GM1 gangliosides, i.p., beginning t