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Effect of glycyrrhizin and its diastereoisomers on the growth of human tumour cells: preliminary findings

โœ Scribed by Monica Malagoli; Mario Castelli; Andrea Baggio; Claudio Cermelli; Laura Garuti; Tiziana Rossi

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
76 KB
Volume
12
Category
Article
ISSN
0951-418X

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โœฆ Synopsis

It is known that some pentacyclic triterpenoids present in nature possess anti-tumour activity. In a recent study we demonstrated that a prolonged glycyrrhizin treatment was effective in modifying the survival pattern of mice with Ehrlich ascites tumour. Moreover, it has been demonstrated that 18a-glycyrrhetinic acid, 18b-glycyrrhetinic acid and glycyrrhizin effectively inhibited the inception and growth of skin tumour. In an in vitro study these drugs also proved effective against the growth and differentiation of mouse melanoma cells. In this work we investigated the effect of 18a-glycyrrhetinic acid, 18b-glycyrrhetinic acid and glycyrrhizin on the growth of human tumour cells: two lymphomas and two leukaemias. The results were compared with those afforded by equimolecular doses of daunorubicin and showed that all three substances were fairly active, particulary against leukaemia cells.

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