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Effect of glycosaminoglycans on fibronectin-mediated cell attachment

✍ Scribed by Robert J. Klebe; Penny J. Mock

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
664 KB
Volume
112
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

In this study, the role of glycosaminoglycans in fibronectin‐mediated cell attachment to collagen has been investigated. While it has been established that fibronectin possesses binding sites for several glycosaminoglycans, it was found that only dextran sulfate and macromolecular heparin could decrease the initial rate of cell attachment to collagen. Low molecular weight heparin was inactive. This study suggests that the glycosaminoglycan binding site of fibronectin plays a role in the mechanism of cell attachment.

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