𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of glucocorticoids on bone density

✍ Scribed by Rehman, Qaiser ;Lane, Nancy E.

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
145 KB
Volume
41
Category
Article
ISSN
0098-1532

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Glucocorticoid therapy is the most common cause of secondary iatrogenic osteoporosis. The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Glucocorticoids induce osteoblast apoptosis and increase osteoclast survival and activity. Most of these effects are mediated through the RANKL‐OPG system but perturbations in gonadal hormone activity and calcium balance may also contribute significantly to bone loss. Future therapies in the treatment and prevention of glucocorticoid‐induced osteoporosis may be targeted at restoring the hormonal and cytokine balance to nullify the apoptotic effect of glucocorticoids on bone forming cells. Med Pediatr Oncol 2003;41:212–216. © 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Radiation-therapy effects on bone densit
Radiation-therapy effects on bone density
✍ Hopewell, John W. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB

## Abstract Only limited data are available on the effects of radiation‐therapy on the mineral content of the bone of children treated for malignancy. The incidence of osteopenia varies between 8 and 23%, but confounding factors were the use of chemotherapy and the effects of prophylactic cranial i

Effect of glucocorticoids on the arterie
Effect of glucocorticoids on the arteries in rheumatoid arthritis
✍ Inmaculada del Rincón; Daniel H. O'Leary; Roy W. Haas; Agustín Escalante 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 89 KB 👁 2 views

## Abstract ## Objective Glucocorticoids are suspected to cause atherosclerosis. Because of the possibility that their antiinflammatory effect may be antiatherogenic, this study investigated the effect of glucocorticoids on the arteries of patients with rheumatoid arthritis (RA). ## Methods We a

Assessment of sex-specific genetic and e
Assessment of sex-specific genetic and environmental effects on bone mineral density
✍ Lillian B. Brown; Elizabeth A. Streeten; Alan R. Shuldiner; Laura A. Almasy; Pat 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB 👁 2 views

## Abstract Although it is widely accepted that genes contribute significantly to the variation in bone mineral density (BMD), the nature of the genetic contribution is poorly defined. There are large gender differences in BMD, although whether sex‐specific genetic effects influencing variation in