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Effect of genotype on steady-state CYP1A1 gene expression in human peripheral lymphocytes

✍ Scribed by Seymour Garte; Sabya Ganguly; Emanuela Taioli

Book ID
113993343
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
96 KB
Volume
65
Category
Article
ISSN
0006-2952

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## Abstract Cytochrome P450 (CYP) 2A6 and __CYP2E1__ are enzymes with a high ability to activate a nitrosamine, 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK), to its potent and ultimate carcinogens. The polymorphic __CYP2A6__ and __CYP2E1__ have been implicated in increased susceptibility to