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Effect of Genetic Background on the Therapeutic Effects of Dehydroepiandrosterone (DHEA) in Diabetes-Obesity Mutants and in Aged Normal Mice

✍ Scribed by Coleman, D. L.; Schwizer, R. W.; Leiter, E. H.

Book ID
118119606
Publisher
American Diabetes Association
Year
1984
Tongue
English
Weight
944 KB
Volume
33
Category
Article
ISSN
0012-1797

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The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.