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Effect of Freezing Rates and Excipients on the Infectivity of a Live Viral Vaccine during Lyophilization

โœ Scribed by Suling Zhai; Raino K. Hansen; Richard Taylor; Jeremy N. Skepper; Raquel Sanches; Nigel K. H. Slater


Book ID
109386972
Publisher
American Institute of Chemical Engineers
Year
2004
Tongue
English
Weight
278 KB
Volume
20
Category
Article
ISSN
8756-7938

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The incorporation of components with covalently attached polyethylene glycol (PEG) into nonviral vectors has been shown to prevent aggregation in serum and extend the circulating half-life of lipid/DNA complexes (lipoplexes) in vivo. The tendency of synthetic vectors to aggregate during processing a