Effect of free radical scavenger (tempol) on intrarenal oxygenation in hypertensive rats as evaluated by BOLD MRI
✍ Scribed by Lu-Ping Li; Belinda S. Y. Li; Pippa Storey; Laura Fogelson; Wei Li; Pottumarthi Prasad
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 132 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To demonstrate a differential response following administration of a free radical scavenger, tempol, in kidneys of hypertensive compared to normotensive rats.
Material and Methods
Data were obtained in spontaneously hypertensive rats (SHR, N = 5). Wistar‐Kyoto rats (WKY, N = 6) were used as normotensive controls.
Results
Consistent with prior reports, SHRs show a significant response to tempol (R~2~*decreased from 40.56 ± 0.66 second^−1^ to 28.58 ± 0.6 second^–1^ in medulla, P < 0.05), while WKY rats exhibit a minimal change (R~2~* measuring 22.36 ± 4.38 second^–1^ pre‐tempol and 21.57 ± 4.78 second^–1^ post‐tempol, in medulla). The post‐tempol R~2~* in SHR was found to be comparable to pre‐tempol values in WKY rats, suggesting an improved medullary oxygenation in SHRs.
Conclusion
Based on both baseline R~2~* values and the differential effect of the free radical scavenger on renal medullary oxygenation, BOLD MRI can distinguish hypertensive from normal kidney in rats. J. Magn. Reson. Imaging 2005;21:245–248. © 2005 Wiley‐Liss, Inc.