Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall

Effect of the ACAT inhibitor CI-976 on p

Effect of the ACAT inhibitor CI-976 on plasma cholesterol concentrations and distribution in hamsters fed zero- and low-cholesterol diets

✍ Brian R. Krause; Richard F. Bousley; Karen A. Kieft; Richard L. Stanfield 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 724 KB

The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like" levels of cholesterol. With a purified diet containing zero dietary cholesterol, CI-976 significantly lowered VLDL cholesterol (VLDL-C), but