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Effect of formulation variables on drug and polymer release from HPMC-based matrix tablets

✍ Scribed by K.C. Sung; Phillip R. Nixon; John W. Skoug; T.Robert Ju; Ping Gao; E.M. Topp; M.V. Patel


Book ID
113368588
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
621 KB
Volume
142
Category
Article
ISSN
0378-5173

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The aim of this study was to determine, whether interactions between a drug and hydrophobic polymer matrix are present, and if so, how they affect the drug release. In addition, the most important formulation parameters, for example porosity or structure of the tablet, which have the greatest impact