Freeze-drying using a partial load is a common occurrence during the early manufacturing stages when insufficient amounts of active pharmaceutical ingredient (API) are available. In such cases, the immediate production needs are met by performing lyophilization with less than a full freeze dryer loa
Effect of formulation design and freeze-drying on properties of fluconazole multilamellar liposomes
โ Scribed by Ola H. El-Nesr; Soad A. Yahiya; Omaima N. El-Gazayerly
- Book ID
- 116700956
- Publisher
- Elsevier
- Year
- 2010
- Tongue
- English
- Weight
- 442 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1319-0164
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The effects of various preservation techniques on the biomechanical properties of bone have been investigated in a rat model. Freezing of the specimens to -20ยฐC, -7O"C, and -196ยฐC did not adversely affect the strength of long bones tested in torsion or of vertebral bodies tested in compression. Free
Liposomes are widely investigated for their use as drug delivery systems, where they have to meet strict stability criteria. Hence, it is of common interest to establish appropriate storage conditions to improve the shelf life of liposomes. In general, long-term stability can be achieved by freezing