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Effect of food-deprivation on rat pancreatic islet cells

✍ Scribed by Aponte, Gregory; Gross, Douglas; Rosenquist, Grace; Mendel, Verne; Yamada, Tadataka

Book ID
123319934
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
432 KB
Volume
4
Category
Article
ISSN
0196-9781

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Islet cell lines were produced by retroviral transduction of SV-40 T antigen to monolayer cultures of neonatal rat islets. One line, RN0-11, showed evolution of phenotypes in vitro. It evolved from a non-hormone secreting cell line to an insulin secreting line. It further developed glucagon producin