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Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

✍ Scribed by Herbert Y. Meltzer; Steven M. Paul; Victor S. Fang

Publisher
Springer
Year
1977
Tongue
English
Weight
283 KB
Volume
51
Category
Article
ISSN
0033-3158

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✦ Synopsis

Cis (alpha)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (beta)-flupenthixol and (-)-butaclamol are not. alpha-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the beta-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

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