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Effect of fluoride and other metobolic inhibitors on intracellular sodium and potassium concentrations in l cells

✍ Scribed by D. O. Quissell; J. W. Suttie

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
483 KB
Volume
82
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Fluoride, iodoacetate, oxamate, 2,4‐dinitrophenol, cycloheximide, and ouabain were studied to determine if any of these inhibitors affected the intracellular concentration of sodium and potassium in an L cell strain of mouse fibroblasts and to determine if the changes observed in these parameters could be correlated with growth rate. The results indicated that (1) the intracellular concentration of sodium and potassium could not be correlated with growth rate, (2) fluoride, iodoacetate, oxamate, 2,4‐dinitrophenol, and cycloheximide at concentrations having an equal effect on growth had a similar effect on the intracellular sodium and potassium concentration These changes were not as great as those seen with ouabain, which at a concentration which did not inhibit growth, had an equal or greater effect on the intracellular sodium and potassium concentration.

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