𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of finite ionic size on the solution of the Poisson-Boltzmann equation: Application to the binding of divalent metal ions to DNA

✍ Scribed by Joseph Granot

Publisher
Wiley (John Wiley & Sons)
Year
1983
Tongue
English
Weight
667 KB
Volume
22
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

The nonlinear Poisson-Boltzmann equation is solved for a cylindrical polyelectrolyte solution containing mono-and divalent counterions and monovalent coions. The finite size of the ions is taken into account by the introduction of the distances of closest approach between the ionic charges and the surface of the polyelectrolyte. The choice of these distances is based on the physicochemical properties of the polyelectrolyte and ions in solution. The effects of the finite ionic size on the distribution of the counterions around the polyelectrolyte and on the local ion concentration and the integrated charge fraction of the divalent cations in the vicinity of the polyelectrolyte are discussed. Theoretical predictions regarding the overall extent of binding and the extent of inner-sphere binding of divalent counterions t o rodlike polyions are compared with the results of nmr studies of the binding of divalent metal ions to DNA.

📜 SIMILAR VOLUMES

Electrostatic binding energy calculation
Electrostatic binding energy calculation using the finite difference solution to the linearized Poisson-Boltzmann equation: Assessment of its accuracy
✍ Shen, Jian; Wendoloski, John 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 599 KB

A full account of how to calculate the electrostatic binding energy using the finite difference solution to the linearized Poisson-Boltzmann equation (FDPB) for protein-ligand systems is described. The following tests show that the statistical and systematic errors due to discrete grid representatio

On the application of polyelectrolyte li
On the application of polyelectrolyte limiting laws to the helix–coil transition of DNA. V. Ionic effects on renaturation kinetics
✍ Gerald S. Manning 📂 Article 📅 1976 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 682 KB

New Brunswick, New Jersey 08903 ## Synopsis The bimolecular rate constant k z for the association of complementary polynucleotide strands has been observed to increase strongly with increasing ionic strength-in fact, proportional to its third or fourth power. This effect is here interpreted quant

On the application of polyelectrolyte li
On the application of polyelectrolyte limiting laws to the helix–coil transition of DNA. III. Dependence of helix stability on excess univalent salt and on polynucleotide phosphate concentration for variable equivalent ratios of divalent metal ion to phosphate
✍ Nancy De Marky; Gerald S. Manning 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 819 KB

## Abstract Using the free energy difference between double‐helix and random‐coil forms of DNA as a measure of the stability of the double helix, we calculate the dependence of the stability on excess univalent cation concentration and on polynucleotide phosphate concentration, both as functions of