The present investigation was designed to evaluate the effects of pre-treatment with the cholinergic muscarinic receptor antagonist, atropine sulfate, or with the cyclooxygenase inhibitor, indomethacin, on adenosine-induced bronchoconstriction in human asthmatics. Eight male subjects with a FEV1 of
Effect of felodipine on histamine and adenosine induced bronchoconstriction in patients with asthma
β Scribed by S. K. Ghosh; P. Rafferty
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 204 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0031-6970
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β¦ Synopsis
The effect of felodipine, a new selective calcium antagonist, was assessed on histamine and adenosine monophosphate (AMP) induced bronchoconstriction in 9 mild atopic asthmatics. Felodipine did not alter the baseline FEV1, but showed a small significant inhibitory effect upon histamine and AMP induced bronchoconstriction.
π SIMILAR VOLUMES
The effects of adenosine and some of its analogues on bronchoconstriction and mediator release were studied in isolated lungs of actively sensitized rats. The influence of two novel cardiotonic drugs, milrinone and sulmazole on these adenosine-induced effects was compared with that of theophylline,