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Effect of extracellular potassium on the electrophysiological effects of UK-68,798, a class III antiarrhythmic agent, in gyinea pig papillary muscle

✍ Scribed by Tao Yang; Påi M Tande; David A Lathrop; Helge Refsum

Book ID
115983150
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
97 KB
Volume
23
Category
Article
ISSN
0022-2828

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Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle
✍ Tao Yang; Pål M. Tande; David A. Lathrop; Helge Refsum 📂 Article 📅 1992 🏛 Springer US 🌐 English ⚖ 713 KB

The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL