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Effect of exogenous growth hormone on somatic growth, gonadal development, and hepatic CYP2C11 and CYP2C12 expression in prepubertal intact male rats

โœ Scribed by Kawai, Masahiko; Bandiera, Stelvio M; Chang, Thomas KH; Bellward, Gail D


Book ID
125942472
Publisher
NRC Research Press
Year
2001
Tongue
French
Weight
376 KB
Volume
79
Category
Article
ISSN
0008-4212

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Gender differences in hepatic sex steroid and drug metabolism result from hormonal regulation of specific cytochrome P450 genes (CYP). In male rats, bile duct ligation (BDL) is associated with down-regulation of the male-specific genes, CYP2C11 and CYP3A2, together with a decrease in serum testoster