Effect of etidronate therapy on bone turnover and bone density in mild paget's disease
β Scribed by Blumsohn, A.; Naylor, K.E.; Assiri, A.M.A.; Eastell, R.
- Book ID
- 121903993
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 157 KB
- Volume
- 17
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Etidronate used in recommended doses (usually 5 mg/kg/day for 6 months) produces symptomatic improvement in approximately 60% of patients. The serum alkaline phosphatase and urinary hydroxyproline are reduced to about 50% of initial values. A sustained remission occurs in many patients
Although the measurement of total alkaline phosphatase activity in serum is a valid index to 8ssess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been dev