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Effect of etidronate therapy on bone turnover and bone density in mild paget's disease

✍ Scribed by Blumsohn, A.; Naylor, K.E.; Assiri, A.M.A.; Eastell, R.


Book ID
121903993
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
157 KB
Volume
17
Category
Article
ISSN
8756-3282

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## Abstract Etidronate used in recommended doses (usually 5 mg/kg/day for 6 months) produces symptomatic improvement in approximately 60% of patients. The serum alkaline phosphatase and urinary hydroxyproline are reduced to about 50% of initial values. A sustained remission occurs in many patients

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Although the measurement of total alkaline phosphatase activity in serum is a valid index to 8ssess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been dev