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Effect of ethanol on hepatotoxicity of acetaminophen in mice and on reactive metabolite formation by mouse and human liver microsomes

โœ Scribed by Kenneth E. Thummel; John T. Slattery; Sidney D. Nelson; Caroline A. Lee; Paul G. Pearson


Book ID
113207375
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
580 KB
Volume
100
Category
Article
ISSN
0041-008X

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Acute viral infection has long been recognized to down-regulate cytochrome P-450 enzymes and subsequently to result in changes in the pharmacological and toxicological responses to xenobiotics. In our previous research, chronic retrovirus infection induced by inoculating a susceptible strain of mice