Effect of ethanol on electrolyte transport and electrogenesis in animal tissues

✍ Scribed by Israel-Jacard, Y. ;Kalant, H.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1965
• Tongue: English
• Weight: 503 KB
• Volume: 65
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030650115

✦ Synopsis

Ethanol 0.087M (400 mg/100 m l ) did not affect the initial loss of KC from guinea-pig brain cortex slices at the start of incubation, but significantly inhibited the subsequent reaccumulation of Kf. Ethanol 0.098 M (450 mg/100 m l ) also significantly inhibited the active reaccumulation of K + by pre-cooled rabbit kidney cortex slices.

In vivo experiments with a n electric eel indicated that ethanol in concentrations of 100 to 700 mg/100 ml (22 to 152 mM) significantly diminished the frequency of spontaneous low-voltage electrogenesis.

These findings, together with others in the literature, suggest that ethanol inhibits the active transport of cations by many types of cell, at concentrations relevant to non-lethal intoxication.