𝔖 Bobbio Scriptorium
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Effect of ethanol during hepatitis B virus infection in chimpanzees

✍ Scribed by Edward Tabor; Robert J. Gerety; Lewellys F. Barker; Colin R. Howard; Arie J. Zuckerman

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
462 KB
Volume
2
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

To determine whether the use of ethyl alcohol (ethanol, C~2~H~5~ OH) may increase the liver damage caused by hepatitis B virus infection, ethanol was infused into four chimpanzees on one or two occasions during the course of natural or experimentally induced hepatitis B virus infections. A fifth chimpanzee, without active hepatitis B virus infection, served as a control. Moderate elevations of serum aspartate or alanine aminotransferases occurred in four of the five chimpanzees, including the control chimpanzee, in direct association with ethanol infusion; pre‐existing enzyme elevations persisted in a fifth chimpanzee. No alteration occurred in the titers of hepatitis B surface antigen or of antibody to hepatitis B core antigen in three of the four infected chimpanzees. There was no significant alteration in the course of hepatitis B virus infection by ethanol infusion in these chimpanzees.

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