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Effect of epidermal growth factor on prostaglandin E1-stimulated accumulation of cyclic AMP in fibroblastic cells

โœ Scribed by Wayne B. Anderson; Maria Gallo; Jerome Wilson; Elizabeth Lovelace; Ira Pastan

Book ID
115909323
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
307 KB
Volume
102
Category
Article
ISSN
0014-5793

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Mitogenic effect of prostaglandin E1 in
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Addition of prostaglandin E1 (PGE1) to quiescent cultures of Swiss 3T3 cells rapidly elevates the intracellular levels of cAMP and increases the activity of adenylate cyclase in particulate fractions of these cells. In the presence of insulin, PGE1 stimulates the reinitiation of DNA synthesis. Both