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Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2

✍ Scribed by Maria Antonietta Belisario; Amalia Rosa Arena; Rita Pecce; Rita Borgia; Norma Staiano; Francesco De Lorenzo

Book ID
113137427
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
888 KB
Volume
78
Category
Article
ISSN
0009-2797

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## Abstract Primary cultures of human hepatocytes and hepatoma cell line HepG2 are frequently used to evaluate the hepatic disposition of drugs and other xenobiotics. To check the variability of the expression of drug‐metabolizing enzymes in these in vitro models, expression of genes coding for sev