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Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics

โœ Scribed by Thomas E. Wooters; Michael T. Bardo; Linda P. Dwoskin; Narasimha M. Midde; Adrian M. Gomez; Charles F. Mactutus; Rosemarie M. Booze; Jun Zhu


Book ID
116286226
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
405 KB
Volume
219
Category
Article
ISSN
0166-4328

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Mercuric chloride was found to have a biphasic effect on the binding of the radiolabeled stimulant [3H]methylphenidate to membranes from a crude synaptoso-ma1 preparation of rat striatal tissue. Binding was enhanced at low concentrations of HgCl,, reaching a maximum of 62% above control values at 2.