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Effect of endothelin on AQP4 expression and water permeability in cultured rat astrocyte

โœ Scribed by Kazuhiro Tanaka; Yutaka Koyama

Book ID
116777152
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
111 KB
Volume
65
Category
Article
ISSN
0168-0102

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Endothelins decrease the expression of a
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Some of the aquaporins (AQPs), a family of water channel proteins, are expressed in astrocytes. The expression of astrocytic AQPs is altered after brain insults, such as ischemia and head trauma. However, little is known about the regulation of AQP expressions. Endothelins (ETs), which are vasoconst

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Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, localized in the astrocyte plasma membrane. The regulation of AQP4 is believed to be important for the homeostasis of water in the brain, but the AQP4 regulatory mechanisms are not yet known. In this study, we investigate