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Effect of endothelin-1 on the adrenoreactivity of blood vessels and on the participation of G-proteins and protein kinase C in endothelin-1-induced vasoconstriction

✍ Scribed by T. P. Storozhevykh; D. V. Zagulova; V. G. Pinelis; Kh. M. Markov; M. A. Medvedev; M. R. Baskakov; E. -P. Chabrier; P. Braquet

Publisher: Springer US
Year: 1993
Tongue: English
Weight: 362 KB
Volume: 116
Category: Article
ISSN: 0007-4888
DOI: 10.1007/bf00802838

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## Abstract Previous studies show Src family kinase (SFK) activation is involved in a response that stimulates Na,K‐ATPase. Here, we tested whether SFK activation is involved in the Na,K‐ATPase response to endothelin‐1 (ET‐1). Intact porcine lenses were exposed to 100 nM ET‐1 for 5–30 min. Then, th