A mutated form of the EGF receptor (EGFRvIII), resulting from deletion of exons 2-7, is an oncogenic protein that is expressed in multiple human tumors. This mutation induces ligand-independent activation of the EGFR tyrosine kinase and thereby can initiate unregulated cell growth and tumorigenesis.
β¦ LIBER β¦
Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis
β Scribed by Ivan Jozic; Samar C. Saliba; M. Alejandro Barbieri
- Book ID
- 116179046
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 843 KB
- Volume
- 525
- Category
- Article
- ISSN
- 0003-9861
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