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Effect of efavirenz on the pharmacokinetics of ketoconazole in HIV-infected patients

✍ Scribed by Somchai Sriwiriyajan; Werawath Mahatthanatrakul; Wibool Ridtitid; Sutep Jaruratanasirikul

Publisher
Springer
Year
2007
Tongue
English
Weight
116 KB
Volume
63
Category
Article
ISSN
0031-6970

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To evaluate methodology for in vivo interaction studies of benzodiazepines (BZs) and ketoconazole (KCZ) in animal models, this study assessed the pharmacokinetics and electroencephalographic (EEG) effect of KCZ, and suitable dosage regimens of KCZ to maintain sufficiently high KCZ concentrations to