Effect of drug chirality on the skin permeability of ibuprofen
β Scribed by F. Cilurzo; E. Alberti; P. Minghetti; C.G.M. Gennari; A. Casiraghi; L. Montanari
- Book ID
- 108147045
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 295 KB
- Volume
- 386
- Category
- Article
- ISSN
- 0378-5173
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π SIMILAR VOLUMES
The stratum corneum, the rate-limiting barrier in transdermal drug delivery, is chiral in nature and enantiomers behave differently with respect to their transport across the skin, resulting in enantioselective permeation. The permeation characteristics of individual enantiomers of metoprolol free b
The objective was to assess the impact of propylene glycol (PG), a common cosolvent in topical formulations, on the penetration of ibuprofen into human skin in vivo. Drug uptake into the stratum corneum (SC), following application of saturated formulations containing from 0 to 100% v/v PG, was asses