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Effect of direction of DNA replication on mutagenesis by N-methyl-N-nitrosourea in human cells

✍ Scribed by T. Basic-Zaninovic; F. Palombo; M. Nignami; E. Dogliotti


Book ID
113252480
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
62 KB
Volume
271
Category
Article
ISSN
0165-1161

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N-methyl-N'-nitro-N-nitrosoguanidine (NG) induces certain classes of multiple mutations in yeast at high frequency. By selecting for mutation at one locus (his4 or leu1) one frequently obtains double mutants where another mutation to temperature sensitivity has also been induced. This multiple mutag