Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats

Effects of E. Coli lipopolysaccharide on

Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: Decreased metabolism of ipriflavone due to decreased expression of hepatic CYP1A2 and 2C11

✍ Hye J. Chung; Hee E. Kang; Eun J. Bae; Inchul Lee; Sang G. Kim; Myung G. Lee 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

It was reported that ipriflavone was primarily metabolized via hepatic CYP1A1/2 and 2C11 in rats. In the present study, the expression of CYP1A2 and 2C11 decreased in the liver, but increased in the intestine in rats pretreated with E. coli lipopolysaccharide (ECLPS; an animal model of inflammation)