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Effect of dimerization of a β-turn antimicrobial peptide, PST13-RK, on antimicrobial activity and mammalian cell toxicity

✍ Scribed by Sung-Tae Yang; Jae Il Kim; Song Yub Shin

Publisher
Springer Netherlands
Year
2008
Tongue
English
Weight
250 KB
Volume
31
Category
Article
ISSN
0141-5492

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Effects of dimerization of the cell-penetrating peptide Tat analog on antimicrobial activity and mechanism of bactericidal action
✍ Wan Long Zhu; Song Yub Shin 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB

## Abstract The cell‐penetrating peptide Tat (48–60) (GRKKRRQRRRPPQ) derived from HIV‐1 Tat protein showed potent antibacterial activity (MIC: 2–8 µM). To investigate the effect of dimerization of Tat (48–60) analog, [Tat(W): GRKKRRQRRRPWQ‐NH~2~], on antimicrobial activity and mechanism of bacteric