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Effect of dietary mineral and vitamin D content and parathyroidectomy on the plasma disappearance rate of 1,25-dihydroxy vitamin D3 in rats

✍ Scribed by Dr. Susan K. Paulson; Alexander D. Kenny

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 636 KB
Volume: 6
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510060402

No coin nor oath required. For personal study only.

✦ Synopsis

The plasma disappearance rate of 1,25-dihydroxyvitamin D3 [ 1,25-(OH)*D3] was determined in rats after a single intravenous injection of the tritiated hormone. Tritiated 1,25-(OH)2D3 (120 Ci mmol-I) was administered to rats at a dose of 400 000 dpm kg-' body weight and the animals were bled between 0 and 8 hours. The dose was estimated to produce negligible perturbations in endogenous plasma levels of 1,25-(OH)2D3. The plasma disappearance of 'H-l,25-(0H)2D3 occurred in two phases. The second phase plasma half-life of 1,25-(OH)2D3 in immature 25to 35-day-old animals (4.7 hours) was significantly shorter than the second phase plasma half-life of maturing 49to 65-day-old animals (8.0 hours). Phosphorus deprivation for 12 days significantly prolonged the second phase plasma half-life of 1 ,25-(OH)2D3 from a control value of 4.9 hours to 10.4 hours. Parathyroidectomy, regardless of the plasma calcium concentrations, shortened the second phase plasma half-life of 1,25-(OH)2D3 from control values of 9.1 hours to 5.0 hours. Calcium deprivation for 7 days did not alter the second phase plasma half-life of 1,25-(OH)2D3. Vitamin D deprivation for 5 weeks increased the second phase plasma half-life from 11.0 to 19.9 hours but the difference was not significant.

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