Effect of diabetogenic agents on zinc and calcium concentrations in rabbit pancreatic islet cells
โ Scribed by E. D. Gol'dberg; V. A. Eshchenko; V. D. Bovt
- Publisher
- Springer US
- Year
- 1991
- Tongue
- English
- Weight
- 613 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0007-4888
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Rabbit islets of Langerhans were exposed at 37 "C for 18 h to a low-frequency-pulsed magnetic field, generated in paired Helmholtz coils. Exposed islets showed a reduction of 26.1 -+ 4 . 3 4 in j5Ca'+ content iP < .004). a reduction of 25.1 2 6.3%' in %az+ efflux (P < .006), and a reduction of 35.0
Pancreatic B-cell calcium as histochemically detectable with glyoxal bis (2-hydroxyanil)=GBHA was studied in isolated islets of fed rats. GBHA has previously been shown by us to detect an ionized or readily ionizable Ca-fraction (GBHA-Ca). In the presence of Ca + + (2.5 raM), high glucose (15 raM) i