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Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart

โœ Scribed by S.R. Kimball; L.S. Jefferson

Book ID
117058356
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
391 KB
Volume
156
Category
Article
ISSN
0006-291X

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## Abstract The guanine nucleotide exchange factor (GEF), SmgGDS, promotes nucleotide exchange by several GTPases in both the Ras and Rho families, especially by RhoA. Because RhoA plays an important role in regulating the contraction of vascular smooth muscle cells (VSMC), we examined the expressi