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Effect of Diabetes on Cooling-induced Detrusor Muscle Contraction: Mediation Via Rho-kinase Activation

โœ Scribed by Hishaam N. Ismael; Seham Mustafa; Olav Thulesius


Book ID
116950782
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
598 KB
Volume
75
Category
Article
ISSN
0090-4295

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In the rat isolated main pulmonary artery, we investigated the effect of a tyrosine kinase inhibitor (genistein) and that of a tyrosine phosphatase inhibitor (phenylarsine oxide) on agonist-induced contraction. Genistein (10 microM) reduced the amplitude of the contraction evoked by noradrenaline (0