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Effect of di-n-propylacetate on the ‘binding’ of GABA to a synaptosome-enriched fraction of rat cerebral cortex

✍ Scribed by Beverly M. Kulig; Clara Gonzalez-Portal; E. Somoza; F. V. Defeudis

Publisher
Springer
Year
1977
Tongue
English
Weight
266 KB
Volume
53
Category
Article
ISSN
0033-3158

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✦ Synopsis

The effect of di-n-propylacetate (DPA) on the 'binding' of gamma-aminobutyric acid (GABA) to a synaptosome-enriched fraction of rat cerebral cortex has been examined using differential centrifugation and double-isotope liquid scintillation spectrometry. DPA at 10(-4) M caused a slight decrease in GABA binding. This effect could explain in part the in vivo anticonvulsant and behavioral effects of this drug when administered to animals in high systemic doses.

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