Effect of desferrioxamine on urinary copper and zinc excretion in β-thalassemia major patients

✍ Scribed by Nejat Akar; Mustafa Tekin; Zümrüt Uysal; Ömer Uzunali

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 22 KB
• Volume: 13
• Category: Article
• ISSN: 0896-548X
• DOI: 10.1002/(sici)1520-670x(2000)13:2<195::aid-jtra2>3.0.co;2-9

✦ Synopsis

Twenty-one ␤-thalassemia major patients were included to study urinary zinc and copper excretion before and after high dose desferrioxamine (DF). The mean basal zinc excretion (1193.72 ± 1079.64 g/24 hr) was higher than the mean zinc excretion observed in controls (427.6 ± 74.37 g/24 hr) (P < 0.001). There was no significant difference between urinary copper levels of patients (185.48 ± 175.45 g/dl) and the control group (150.0 ± 37 g/dl) (P > 0.05). No significant difference was observed between the mean basal zinc levels and zinc levels after treatment (1751.06 ± 1462.72 g/24 hr) (P > 0.05). Although the mean copper excretion was decreased following DF treatment (164.16 ± 117.8 g/dl), the difference was not significant (P > 0.1). There was a significant interaction for urinary copper and zinc excretion (r ‫ס‬ 0.413; P < 0.05).