Effect of delayed and/or missed enteric-coated divalproex doses on valproic acid concentrations: simulation and dose replacement recommendations for the clinician

The use of Monte Carlo simulations to st

The use of Monte Carlo simulations to study the effect of poor compliance on the steady state concentrations of valproic acid following administration of enteric-coated and extended release divalproex sodium formulations

✍ Alaa M. Ahmad; F. Douglas Boudinot; William H. Barr; Ronald C. Reed; William R. 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 2 views

## Abstract Divalproex sodium extended‐release (Depakote^®^ ER) is a once daily (QD) formulation for valproic acid that was developed to improve patient compliance and to reduce side effects compared with the standard twice‐daily (BID) delayed release (DR) formulation (Depakote^®^ tablets). However