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Effect of dehydration on the disposition kinetics of erythromycin in rabbits

โœ Scribed by M. Ahmad; S. K. Niazi; T. Ahmad; N. A. Muzaffar; M. Nawaz

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
313 KB
Volume
13
Category
Article
ISSN
0142-2782

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โœฆ Synopsis

The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.

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