Effect of daily dose of chronic haloperidol and chronic apomorphine on behavioral hypersensitivity in the rat
โ Scribed by Bruce J. Kinon; Daniel Merson; John M. Kane
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 557 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0033-3158
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๐ SIMILAR VOLUMES
Rats received daily injections of haloperidol (HAL, 5 mg/kg SC, or IP) or tartaric acid vehicle for 14-21 days. Four to six days after discontinuation of the daily injections, rats were given a single 5-min tail pinch (TP) test. HAL-treated rats showed significantly shorter latencies to display oral
Apomorphine (AP)-elicited sterotypic behavior and striatal 3H-spiroperidol binding sites were studied in rats given 3 weeks of chronic treatment with one of the following neuroleptic drugs: zotepine (10 or 20 mg/kg/day IP); thioridazine (10 or 20 mg/kg/day IP); haloperidol (2 or 5 mg/kg/day IP). On