Dose-response relationships for onset, duration, and magnitude of 3-quinuclidinyl benzilate (QNB) on spontaneous motor activity (SMA) were studied in mice. QNB was administered SC immediately before 2-h test sessions in dose levels differing by a factor of 0.5 log (range 0.1-10.0 mg/kg). For the tot
Effect of d-amphetamine sulphate in combination with CNS depressants on spontaneous motor activity of mice
β Scribed by Vimala H. Sethy; P. Y. Naik; U. K. Sheth
- Publisher
- Springer
- Year
- 1970
- Tongue
- English
- Weight
- 371 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0033-3158
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β¦ Synopsis
The effect of d-amphetamine in combination with pentobarbital sodium, reserpine, chlorpromazine, meprobamate and chlordiazepoxide has been studied on spontaneous motor activity in male mice. d-Amphetamine together with CNS depressants produced a greater effect than amphetamine alone.
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The effect of the D2-antagonist raclopride was investigated in two test situations, which are presumed to involve dopamine (DA) transmission within the nucleus accumbens of the rat. Local injection of d-amphetamine sulphate (10 gg/0.5 gl) produced a marked increase in motor activity, measured as mot
## Abstract ## Objective To investigate the effects of antidepressant therapy plus quetiapine on major depression, motor activity, daytime sleepiness and quality of sleep. ## Methods Patients (__N__β=β27) with major depressive disorder received a standard antidepressant treatment (Venlafaxine, E