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Effect of Cytochrome P450 2D6 Genotype on Maternal Paroxetine Plasma Concentrations during Pregnancy

✍ Scribed by Mrs F. F. Tessa Ververs, Heronimus A. M. Voorbij, Petra Zwarts, Svetlana V. Belitser, Toine C. G. Egberts, Gerard H. A. Visser, Alfred F. A. M. Schobben

Book ID
119930658
Publisher
Springer International Publishing AG
Year
2009
Tongue
English
Weight
186 KB
Volume
48
Category
Article
ISSN
0312-5963

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The interaction of antiparasitic drugs with the polymorphic cytochrome P450 2D6 was studied in human liver microsomes. Of ten different drugs tested, three quinolines, oxamniquine, primaquine and chloroquine inhibited microsomal CYP2D6-catalysed formation of l'hydroxybufuralol at concentrations tha